Where Science Meets Specificity
Precision in RNA Therapeutics
sxRNA Technologies, Inc. is a company that engineers RNA nanoswitches, which allow RNA therapeutics to become tissue-specific.
Current RNA therapeutics lead to a number of issues. Success has been limited in making tissue specific delivery mechanisms for RNA-based drugs.
RNA therapeutics are delivered throughout your body, including to cells that are not the intended or ideal targets. Like a drug going to the wrong location, this can lead to significant and often severe side effects.
The inability to target cells specifically, greatly reduces the feasibility of new RNA therapeutics, as side effects have the potential to be wide-ranging and significant.
sxRNA has Developed a New Technology Platform for RNA Therapeutics
sxRNA has engineered first-of-its-kind, RNA nanoswitches which allows for new therapeutics to become tissue-specific. Our revolutionary sxRNA technology enables targeted RNA therapies, unlocking a future of safer, more effective treatments.
What this Means for the Future of RNA Therapeutics
sxRNA is a gamechanging technology for RNA therapeutics. In addition to increasing safety and patient comfortability, sxRNA should also integrate seamlessly into the pipeline of most established RNA therapeutics to yield a better product.
Targeted Therapy
With the ability to target not only specific organs, but also cells misbehaving in a specific way, this technology is the epitome of "precision medicine."
Reduced Side Effects
Because the delivered mRNA is not active in off-target cells, there is potential for a drastic reduction in side-effects, enabling sxRNA therapies safer and the patients more comfortable.
Broad Application Potential
sxRNA is essentially a plug-and-play solution for any mRNA-based therapeutic. The message is inconsequential to function, as long as a unique trigger RNA can be identified in the target cells.
Interested in
Partnering with
?
We are actively seeking potential partnerships to explore new opportunities within the space of RNA therapeutics. Our sxRNA platform is ideally suited for the formation of partnerships with industry and academic collaborators.
Expanding on Our Technology is Near Limitless
sxRNA technology is transforming the landscape of medical research and treatment. By targeting specific cellular mechanisms, it opens new avenues for addressing complex diseases. Our platform not only enhances understanding but also accelerates the development of effective therapies.
Alzheimer’s Therapy
Developing an sxRNA lock and key for Senescent cells found in the brains of Alzheimer’s patients
Organoid Kits
Creating an organoid ‘kit’ for researchers studying and developing therapies for Alzheimer’s Disease
Antiviral Treatments
Creating an sxRNA reporter that selectively targets Epstein-Barr Virus infected cells
We're also exploring additional applications, maximizing the potential of this new platform.
Our sxRNA platform can be applied in a wide array of areas in addition to what we are currently working on. Some of the collaborations we are involved in are mentioned here. If you would like to partner on a project of your own, sxRNA would love to hear about it!
RNA Therapeutics
With the breakthrough of mRNA therapeutics onto the pharmaceutical scene, the stage is primed for sxRNA. We envision our technology playing a role in the therapies listed above, as well as cancer therapies, and treatment of other neuro-degenerative diseases.
Diagnostics
sxRNA-based switches are highly sensitive and highly specific. Our switches are being used to design point-of-care diagnostics. We are currently in partnership for the development of a serum-based diagnostic for early detection of cancer relapse.
Biomanufacturing
sxRNA has several potential applications in the biomanufacturing space. A broad application is to potentially reduce time to find the best clones in a population from months to weeks. Due to the controllable switch activity of sxRNA, this can further be built on to greatly enhance the amount of protein produced in cells that can manufacture them in abundance, but do not tolerate the protein product well.
Additional Applications through Partnerships
The plug-and-play nature of the sxRNA technology lends it to be used in a wide variety of applications. Some of these are shown here. We are actively seeking partnerships to push forward other applications as well. If you believe our technology can help with your products or research, we probably agree! Feel free to reach out and we'll talk specifics.